Evidence of codon usage in the nearest neighbor spacing distribution of bases in bacterial genomes

► Internucleotide distances in bacterial genomes have an average and fluctuations. ► Genomic sequences can be classified as linear or piecewise linear. ► Unfolding allows a comparison between genomes coming from different organisms. ► The nearest-neighbor spacing distributions distinguish between bacterial genera. ► The codon usage fixes the shape of the nearest-neighbor spacing distributions.