Structural disorder and local order of hNopp140

► hNopp140 belongs to the premolten globule class of IDPs. ► hNopp140 uses pre-structured motifs to form diverse interactions. ► hNopp140 binding to TFIIB involves the elevation of helical content. ► The diverse cellular functions of hNopp140 stem from its disordered state. ► The high level of phosphorylation of hNopp140 is linked to its disordered nature.