Proximal fluid proteomics for the discovery of digestive cancer biomarkers

In the present review, the state-of-the-art of proteomic investigations aimed at identifying new cancer biomarkers in fluids surrounding gastrointestinal malignancies is summarized. A comprehensive catalog of proteomic studies in which potential cancer biomarkers from gastrointestinal fluids have been identified and assessed for their diagnostic performances is also provided. This article is part of a Special Issue entitled: Biomarkers: A Proteomic Challenge.