Endothelium-dependent vasodilator and antioxidant properties of a novel enzymatic extract of grape pomace from wine industrial waste

► GP extracted by enzymatic process shows antioxidant activity and polyphenol bioactive components. ► GP-EE induced endothelium- and NO-dependent in different vascular beds. ► GP-EE reduced superoxide anion produced by ET-1 stimulated vascular tissue.