Human IgE binding and in vitro digestion of S-OVA

► In vitro digestibility and human IgE-binding of S-OVA was firstly studied. ► S-OVA showed a much lower reactivity against IgE than OVA. ► S-OVA was more resistant to proteolysis than its native form. ► Gastro intestinal digestion diminished the differences between OVA and S-OVA regarding IgE-binding.