Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages

► We study the anti-inflammatory effects of phloretin and phlorizin. ► Phloretin reduces the levels IL-6, TNF-α, iNOS and COX-2 via NF-κB and MAPK. ► Phlorizin does not suppress the inflammatory response. ► Phloretin can develop as an anti-inflammatory drug or health food.