Determination of nonylphenol ethoxylate metabolites in vegetables and crops by high performance liquid chromatography-tandem mass spectrometry

► LC-MS/MS as analytical technique to the determination of degradation substances of NPEOs. ► Sample pretreatment developed by liquid-liquid extraction combined with SPE. ► Parameters of the extraction, cleanup and mass detection were optimised. ► Developed method has good performance of precision, linearity, LODs and LOQs. ► Results show that NP residues are widespread in vegetables and crops.