Effect of AATI, a Bowman-Birk type inhibitor from Apios americana, on proliferation of cancer cell lines

► AATI showed the same or stronger inhibitory than SSBI on the proliferation rate. ► The treatment of AATI induced apoptosis. ► The DNA was broken into fragment state by treatment with AATI. ► The Apios tuber can be helpful to declining the cancer incidence.