Evaluation of the anti-angiogenic potential of hydroxytyrosol and tyrosol, two bio-active phenolic compounds of extra virgin olive oil, in endothelial cell cultures

► In vitro evaluation of tyrosol and hydroxytyrosol as anti-angiogenic compounds. ► Hydroxytyrosol (but not tyrosol) inhibits three key steps of angiogenesis. ► Hydroxytyrosol changes endothelial cell cycle distribution. ► Hydroxytyrosol inhibits endothelial cell matrix metalloproteinase 2. ► Hydroxytyrosol (but not tyrosol) is a new multi-targeted anti-angiogenic compound.