Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L.

► The major constituents of R. officinalis fractions and essential oil were determined. ► Fractions and essential oil of R. officinalis reduced immobility time in the TST. ► Carnosol and betulinic acid produced antidepressant-like effect in the TST. ► Results support the notion that R. officinalis has antidepressant properties.