Screening for ligands of human aromatase from mulberry (Mori alba L.) leaf by using high-performance liquid chromatography/tandem mass spectrometry

► We discovered firstly inhibitors of aromatase from mulberry (Mori albaL.) leaf. ► We used a method by HPLC-MS instead of bio-experiment to discover the inhibitors. ► We have verified our theory by a bio-assay model system. ► The most quality of our method is fast and efficient.