Neuroprotective effect of alkyl hydroxytyrosyl ethers in rat brain slices subjected to a hypoxia-reoxygenation model

► Hydroxytyrosyl alkyl ether derivatives exerted a neuroprotective effect in rat brain slices. ► The inhibition of lipid peroxidation was directly related to the cytoprotective effect. ► The length of the alkyl side-chain was related to the cytoprotective effect. ► The cytoprotective effect was maximal in the range of C4-C8.