HPLC-MS analyses and bioactivities of novel chemicals in Devil's club (Oplopanax horridus (Sm.) Miq.)

► The Devil's club showed the strong antioxidant and anti-proliferation activity. ► The CHCl3 extract contained more bioactive phenolics than other solvent extracts. ► Eight bioactive compounds in the plant were identified with the aid of HPLC-UV-MS. ► The ferulic acid and its derivatives contributed to the antioxidant ability of the Devil's club.