Excretion profile of glycyrrhizin metabolite in human urine

► 3β-Monoglucuronyl-18β-glycyrrhetinic acid is a metabolite of glycyrrhizin. ► Urine excretion profile of 3β-monoglucuronyl-18β-glycyrrhetinic acid was determined. ► Six volunteers ingested 600 mg of glycyrrhizin in the morning and, after 2 weeks, in the evening. ► The amount of excreted metabolite in urine was 0.31-0.67% of the ingested dose.