Quantitative analysis of glycoconjugate precursors of guaiacol in smoke-affected grapes using liquid chromatography-tandem mass spectrometry based stable isotope dilution analysis

► A method for quantifying guaiacol glycoconjugates has been developed and validated. ► Glycoconjugates accumulated in grape berries following grapevine exposure to smoke. ► Higher concentrations of glycoconjugates were present in grape skins compared with pulp.