کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10544953 | 963613 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genotoxicity and antigenotoxicity of Origanum oil and carvacrol evaluated by Ames Salmonella/microsomal test
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
This study evaluates the genotoxic and antigenotoxic effects of the essential oil of Origanum onites L. and carvacrol that are used in medicine, flavouring of food and crop protection by Ames Salmonella/microsomal test. The mutagenic activity was initially screened using Salmonella typhimurium strains TA98 and TA100, with or without S9 metabolic activation. No mutagenicity was found in the oil to the both strains either with or without S9 mixture whereas significant mutagenic activity was induced by carvacrol generally in the absent of metabolic activity. The oil and its major constituent carvacrol were finally tested for their antimutagenic activity with 30Â min standard preincubation time. It was shown that both of them strongly inhibited mutagenicity induced by 4-nitro-o-phenylenediamine and 2-aminofluorene in both strains with or without S9, respectively. These results indicate significant antimutagenicity of the essential oil and carvacrol in vitro, suggesting its pharmacological importance for the prevention of cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 93, Issue 3, December 2005, Pages 551-556
Journal: Food Chemistry - Volume 93, Issue 3, December 2005, Pages 551-556
نویسندگان
Evrim Ipek, Hulya Zeytinoglu, Sezer Okay, Berrin A. Tuylu, Mine Kurkcuoglu, K. Husnu Can Baser,