کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10550220 967034 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A sensitive liquid chromatography-tandem mass spectrometry method for the quantification of mometasone furoate in human plasma
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
A sensitive liquid chromatography-tandem mass spectrometry method for the quantification of mometasone furoate in human plasma
چکیده انگلیسی
A robust, rapid, selective and sensitive liquid chromatography-negative atmospheric pressure chemical ionization (LC-(APCI−)-MS-MS) method has been developed for the quantification of mometasone furoate (MF) in human plasma utilizing a solid-phase extraction clean-up step and 13C-fluticasone propionate as internal standard. The intra- and inter-day coefficients of variation were ≤15% and the lower limit of quantification (LLOQ) was 15 pg/ml. This method is ideally suited for pharmacokinetic investigations of low MF levels following inhalation of MF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography B - Volume 819, Issue 1, 5 May 2005, Pages 175-179
نویسندگان
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