کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10553299 967726 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polysaccharides from Flammulina velutipes improve scopolamine-induced impairment of learning and memory of rats
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Polysaccharides from Flammulina velutipes improve scopolamine-induced impairment of learning and memory of rats
چکیده انگلیسی
Flammulina velutipes has been reported to be beneficial in learning and memory capabilities, but the mechanisms underlying this remain unclear. In this study, Morris water maze and biochemical analyses of rat brain were used to evaluate the effects of F. velutipes polysaccharides (FVP) on scopolamine-induced learning and memory impairments. Results suggested that FVP significantly decreased the escape latency and total swimming distance of rats in the hidden platform test and increased the numbers of platform crossing and swimming distance of rats in the probe test. Biochemical examinations revealed that FVP significantly elevates SOD and GSH-Px activities, as well as neurotransmitter levels. The increased acetylcholine content owed to the increased acetylcholine acetyltransferase activity and decreased acetylcholinesterase activity. Moreover, learning and memory associated signalling pathways were activated by FVP elevating the expression of connexin 36 and p-CaMK II. These results conclusively proved that FVP is a potent agent against the progression of cognitive impairment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 18, Part A, October 2015, Pages 411-422
نویسندگان
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