کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10553304 | 967726 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cellular and molecular mechanisms of probiotics effects on colorectal cancer
ترجمه فارسی عنوان
مکانیسم های سلولی و مولکولی اثرات پروبیوتیک بر سرطان کولورکتال
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کلمات کلیدی
سرطان روده بزرگ، میکروبیوتا، رژیم غذایی، باکتری های پروبیوتیک،
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Colorectal cancer is the most common malignancy of the gastrointestinal tract and it seems the colonic microbiota plays a significant role in the aetiology of colorectal cancer because it can influence many aspects of intestinal tract health including its physiology, metabolism, development, and immune homeostasis. Hence, all factors modulating the gut microflora and their metabolism are very interesting in cancer prevention. Probiotic bacteria have been examined for anti-cancer effects and different mechanisms were suggested about their anti-tumour functions. This study reviewed some of the possible cellular and molecular mechanisms of probiotics such as influencing intestinal microbial composition and pathogenic bacteria, the production of biological substance like short chain fatty acids and conjugated linoleic acid, inactivation of carcinogenic compounds especially those derived from food, improvement of intestinal barrier function, modulation of immune responses, apoptosis and anti-proliferative effects and antioxidant function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 18, Part A, October 2015, Pages 463-472
Journal: Journal of Functional Foods - Volume 18, Part A, October 2015, Pages 463-472
نویسندگان
Zeinab Faghfoori, Bahram Pourghassem Gargari, Amir Saber Gharamaleki, Hassan Bagherpour, Ahmad Yari Khosroushahi,