Ankaflavin regulates adipocyte function and attenuates hyperglycemia caused by high-fat diet via PPAR-γ activation

► Ankaflavin (AK) attenuated insulin resistance in high-fat diet-induced mice. ► AK avoided fatty acid accumulation via promoting lipolysis in mature adipocytes. ► AK promoted insulin receptor and p-Akt to increase glucose uptake in adipocytes. ► The effect of AK on anti-diabetes was abolished by PPAR-γ antagonist GW9662.