Nigella sativa L. improves lipid profile and prevents atherosclerosis: Evidence from an experimental study on hypercholesterolemic rabbits

► We determined effects of Nigella sativa on its risk factors in hypercholesterolemic rabbits. ► Using this plant decreased fatty streak formation, total cholesterol and low-density lipoprotein. ► NS had anti-atherogenic cardioprotective properties. ► Using this plant with fat-rich diets simultaneously may reduce their adverse health effects.