The p38 and NFκB signaling protein activation involved in glycitein protective effects on isoproterenol-treated H9c2 cardiomyoblast cells

► Protective effect of glycitein on H9c2 cardiomyoblasts treated with isoproterenol. ► Isoproterenol treatment induces cell apoptosis via mitochondrial dependent pathway. ► Glycitein suppresses pro-apoptotic proteins in H9c2 cell treated with isoproterenol. ► Glycitein increases pro-survival proteins in H9c2 cell treated with isoproterenol. ► Glycitein is an effective and natural selective estrogen receptor modulator (SERM).