کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10553422 967763 2013 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lactobacillus reuteri CRL1101 beneficially modulate lipopolysaccharide-mediated inflammatory response in a mouse model of endotoxic shock
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Lactobacillus reuteri CRL1101 beneficially modulate lipopolysaccharide-mediated inflammatory response in a mouse model of endotoxic shock
چکیده انگلیسی
Lactobacillus reuteri CRL1101 was found to reduce inflammatory and oxidative damage during endotoxic shock induced by lipopolysaccharide (LPS) administration in mice. This beneficial effect was related to the capacity of both the cell structure as well as their secreted products to act synergistically to induce a tolerogenic profile in immune cells. The study supports the idea that, although probiotic microorganisms may exert their beneficial effects due to their well-known ability to modulate intestinal immunity, these effects are not restricted to the gastrointestinal tract. In addition, we demonstrated that the in vitro screening of lactobacilli strains is still a powerful approach to discriminate the potential probiotic bacteria for specific functions that could be later studied in animal models. From the systematic studies reported here, L. reuteri CRL1101, a strain with technological potential usefulness in dairy products, is proposed as novel probiotic candidate for the prevention and control of systemic inflammatory disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 5, Issue 4, October 2013, Pages 1761-1773
نویسندگان
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