Proteomic analysis of zebrafish (Danio rerio) embryos exposed to cyclosporine A

► Differential protein expression analysis in zebrafish embryos exposed to CsA. ► CsA toxicity resulted in various developmental abnormalities. ► Thirty seven differentially expressed proteins were identified post CsA treatment. ► Validation of the discovery phase data was done by QPCR and immunoblotting. ► CsA treatment in early development alters expression of essential proteins.