Renal fibrosis and proteomics: Current knowledge and still key open questions for proteomic investigation

► Proteomics studies of the fibrotic pathophysiological mechanisms have been performed in cell cultures, animal models and human tissues, addressing some of the key issues. ► This article review proteomics contribution to the raising current knowledge on renal fibrosis biology. ► This article mention seminal open questions to which proteomic techniques and proteomists could fruitful contribute.