Direct characterization of target podocyte antigens and auto-antibodies in human membranous glomerulonephritis: Alfa-enolase and borderline antigens

► We identified α-enolase as new auto-antigens in membranous glomerulonephritis (MGN). ► We studied a-enolase using a proteomics approach. ► This new auto-antigen was validated in 131 MGN patients. > α-enolase may be implicated in the pathogenesis of human MGN.