Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF)

► 132 proteins were identified to form complex with HDGF by SBP/FLAG-TAP coupled with LC-MS/MS. ► RNAs were also identified in the HDGF complex by SBP-tag based RNA co-immunoprecipitation assay. ► HATH domain was essential for HDGF protein-protein and protein-RNA interactions. ► The interactome study suggests HDGF is a multifunctional protein.