Identification Keratin 1 as a cDDP-resistant protein in nasopharyngeal carcinoma cell lines

► The first study to apply comparative proteomics (2-DE and MS) to screen drug resistance-related proteins in cDDP-resistant NPC cells. ► The first study to obtain 15 drug resistance-related proteins in NPC cells. ► The first study to identify Keratin 1(KRT1) as a cDDP-resistant protein in NPC cells.