Altered expression of talin 1 in peripheral immune cells points to a significant role of the innate immune system in spontaneous autoimmune uveitis

► Leukocytes change protein expression in spontaneous autoimmune disease. ► DIGE reveals decreased abundance of talin 1. ► Talin 1 has important functions in cell migration and integrin activation. ► Differential expression of talin 1 could be assigned to innate immune cells.