Dasatinib, imatinib and staurosporine capture compounds - Complementary tools for the profiling of kinases by Capture Compound Mass Spectrometry (CCMS)

► Dasatinib and imatinib Capture Compounds were synthesized ► Drug-protein interactions were profiled in comparison to staurosporine ► Distinct kinase inhibitor specific sub-kinomes were identified ► Specific capturing of the kinase p38α was observed with the imatinib Capture Compound ► Specific non-kinase off-targets were identified for both imatinib and dasatinib