RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis

► Protein arrays used to identify tumour-associated autoantigens in ALCL patients. ► RNASET2, LPPR3 and FADD identified as TAAs in ALK-negative ALCL. ► Circulating anti-RNASET2 autoantibodies recognise eukaryotically expressed RNASET2 protein. ► RNASET2 protein expression observed in ALK-negative ALCL (81%) and ALK-positive ALCL (65%) and some other lymphomas.