Effect of the myosin light chain kinase inhibitor ML-7 on the proteome of hearts subjected to ischemia-reperfusion injury

► Myosin light chain kinase inhibitor ML-7 is cardioprotective against ischemia. ► Proteomic analysis identified 3 possible protein targets of ML-7 in ischemia. ► ML-7 regulates energy metabolism and structural proteins to confer cardioprotection.