Muscle tissue as an endocrine organ: Comparative secretome profiling of slow-oxidative and fast-glycolytic rat muscle explants and its variation with exercise

► We have established the first 2-DE analysis of rat whole muscle explants secretomes. ► Muscle secretion pattern varies with muscle fiber-type constituents. ► Muscle secretome is affected by just 1 week of exercise training. ► Among others, DJ-1 and FABP-3 could be considered potential myokines.