MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma

► MALDI imaging identifies novel proteomic biomarkers in Barrett's adenocarcinoma. ► COX7A2 and S100-A10 were found as tumor development markers. ► TAGLN2 was identified as metastasis indicating marker. ► High prognostic impact of TAGLN2 and COX7A2 was uncovered by Kaplan-Meier analyses. ► S100-A10 was identified as novel tumorbiological independent prognostic marker.