Mark Twain: How to fathom the depth of your pet proteome

► The march of combinatorial peptide ligand libraries (CPLLs) in conquering the low-abundance proteome (LAP) ► A focus on urine, sera and tissue “invisible” species ► Can we use CPLLs as a two-dimensional technique? “Yes we can” (B. Obama, unpublished). ► Massive sample overloads are the key to conquering LAPs. ► At least a three-orders of magnitude signal amplification in LAP detection with CPLLs. Don't be bashful, try them!