Extreme diversity of scorpion venom peptides and proteins revealed by transcriptomic analysis: Implication for proteome evolution of scorpion venom arsenal

► More than 200 scorpion venom peptides and proteins were identified by transcriptome analysis, expanding venom composition. ► These toxic compositions were categorized into 15 types, including two novel types, opening new avenues for drug discovery. ► Multiple toxin types were continuously recruited into the venom proteome during the evolution process of scorpion lineages. ► Proteome evolution of the scorpion venom arsenal was firstly clarified by comparative transcriptome and molecular phylogeny.