Synthetic heparin and heparan sulfate oligosaccharides and their protein interactions

- Heparin and heparan sulfate bind many proteins important to physiology and disease.
- Well-defined oligosaccharides can be accessed by chemical or chemoenzymatic means.
- Chemical synthesis advanced to deliver compounds of various lengths and complexity.
- Chain elongation by bacterial enzymes enhanced control in chemoenzymatic approach.
- Bioassay of the synthetic sugars gave insights to features required for function.