کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10565031 971557 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protein semisynthesis and expressed protein ligation: chasing a protein's tail
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
Protein semisynthesis and expressed protein ligation: chasing a protein's tail
چکیده انگلیسی
The adaptation of native chemical ligation to protein semisynthesis has become a powerful way to address problems in the analysis of protein structure and function. In particular, the exploitation of nature's inteins in expressed protein ligation is now a standard approach in the study of proteins. Site-specific incorporation of unnatural amino acids, biophysical probes and post-translational modifications in proteins have led to new insights into enzyme mechanisms, protein folding, ion channel function, translation and signaling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 9, Issue 6, December 2005, Pages 561-569
نویسندگان
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