کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10565032 971557 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The preparation and in vivo applications of caged peptides and proteins
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
The preparation and in vivo applications of caged peptides and proteins
چکیده انگلیسی
Cellular behavior, such as mitosis and motility, are controlled by both when and where specific intracellular signaling pathways are activated in response to environmental cues. Analogous temporally and spatially controlled events occur throughout the lifetime of an organism (e.g. embryogenesis). Consequently, reagents that can be switched on (or off) at any time or at any place in a cell, a tissue, or a living animal, represent the means by which the biochemical basis of spatially and temporally sensitive biological behavior can be evaluated. This review summarizes recent advances in the design and synthesis of light-activated ('caged') peptides and proteins as well as the application of these caged reagents to unanswered questions in biology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 9, Issue 6, December 2005, Pages 570-575
نویسندگان
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