کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10565041 | 971557 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protein surface recognition and proteomimetics: mimics of protein surface structure and function
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
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چکیده انگلیسی
Due to their key roles in a number of biological processes, protein-protein interactions are attractive and important targets, typically involving areas greater than 6 nm2. The disruption of such interactions remains a challenging feat but, in recent years, there has been considerable progress in the design of proteomimetics: molecules that mimic the structure and function of extended regions of protein surfaces. In particular, porphyrins, calixarenes, α-helical mimetics and small molecules have successfully modulated significant protein-protein interactions, including those involved in cancer and HIV.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Chemical Biology - Volume 9, Issue 6, December 2005, Pages 632-638
Journal: Current Opinion in Chemical Biology - Volume 9, Issue 6, December 2005, Pages 632-638
نویسندگان
Steven Fletcher, Andrew D Hamilton,