Radical SAM-mediated methylation reactions

- A subset of radical SAM enzymes catalyzes methylation reactions.
- Radical SAM methylating enzymes expand the scope of methylation substrates.
- RlmN and Cfr add a methylene fragment, originating from SAM, into the substrate.
- Trp methylation by TsrM requires both methylcobalamin and a [4Fe-4S] cluster.