Transcriptomics in the RNA-seq era

► Transcriptomics is a 'true' 'omics technology. ► Bioinformatics methods are developing rapidly but lack consensus approach. ► De novo transcriptome assembly and single cell RNA-seq are now viable protocols. ► Several recent 'discoveries' have turned out to be artifacts - 'MacArthur's Law'. ► ENCODE project results will enhance our understanding of transcriptional control.