Emerging roles for protein S-palmitoylation in immunity from chemical proteomics

► The palmitate chemical reporter and the acyl-biotin exchange methods for studying protein S-palmitoylation are presented. ► The role of S-palmitoylation in the control of the immune response is highlighted. ► Recent S-palmitoyl-proteome studies performed in T cells, dendritic cells, macrophages, and B cells using new chemical proteomic methods are reviewed.