Effective heterogeneous hydrolysis of phosphodiester by pyridine-containing metallopolymers

The copper (II) complex of a simple pyridine- and amide-containing copolymer serves as an effective catalyst for heterogeneous hydrolysis of the prototypical phosphodiester bis(p-nitrophenyl)phosphate at pH 8.0 and 25 °C with a first-order rate constant of kcat = 8.3 × 10−6 s−1, corresponding to a catalytic proficiency of 75-thousand folds.