Topoisomerase II inhibition activity of new square planar Ni(II) complexes containing N-substituted thiosemicarbazones: Synthesis, spectroscopy, X-ray crystallography and electrochemical characterization

► New Ni(II) thiosemicarbazone complexes have been synthesized and characterized by analytical, and X-ray crystallography. ► They were subjected to test their DNA topoisomerase II inhibition efficiency. ► The complex [Ni(Nap-mtsc)(PPh3)] (3) showed 95% inhibition which was more potent than the activity of conventional standard Nalidixic acid.