Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) matrine with Ga(III), Au(III), Sn(IV) ions, and DNA binding studies

Three new compounds of Ga(III), Au(III), Sn(IV) with matrine have been synthesized and structurally characterized. The Ga(III) and Au(III) compounds exhibit enhanced cytotoxicity vs. free matrine, and the interactions with DNA and TOPO I were studied.