کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10574218 | 976519 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sterically hindered complexes of platinum(II) with planar heterocyclic nitrogen donors. A novel complex with 1-methyl-cytosine has a spectrum of activity different from cisplatin and is able of overcoming acquired cisplatin resistance
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
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چکیده انگلیسی
In vitro grow inhibition assays have been performed on the most water soluble complex 3. The results indicate that this complex is characterized by a potent growth inhibitory activity with mean IC50 value (in a panel of 11 human tumor cell lines) of 1.1 μM to be compared with a mean value of 3.8 μM for cisplatin. The same compound also appears to completely overcome the acquired cisplatin resistance stemming from reduced uptake or a multifocal mechanism, thus pointing to a mechanism of action distinctly different from that of cisplatin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 100, Issue 11, November 2006, Pages 1849-1857
Journal: Journal of Inorganic Biochemistry - Volume 100, Issue 11, November 2006, Pages 1849-1857
نویسندگان
Nicola Margiotta, Giovanni Natile, Francesco Capitelli, Francesco P. Fanizzi, Angelina Boccarelli, Pietro De Rinaldis, Domenico Giordano, Mauro Coluccia,