کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10574939 | 976680 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activity of some platinum(II/IV) complexes with O,O-n-butyl-and O,O-n-pentyl-ethylenediamine-N,Nâ²-di-3-propanoate and halogeno ligands against HeLa and K562 cell lines and human PBMC
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This paper reports on syntheses and characterization of chlorotribromo(O,O-n-butyl-ethylenediamine-N,Nâ²-di-3-propanoate)platinum(IV) [II], dichlorodiiodo(O,O-n-butyl-ethylenediamine-N,Nâ²-di-3-propanoate)platinum(IV) [III], and dichloro(O,O-n-butyl-ethylenediamine-N,Nâ²-di-3-propanoate)platinum(II) [V] complexes, with the formulae [Pt(dbeddp)Br3Cl], [Pt(dbeddp)Cl2I2] and [Pt(dbeddp)Cl2], respectively. The complexes were characterized by elemental analysis, infrared, 1H and 13C NMR spectroscopy and electrospray mass spectrometry. In the aim to assess the selectivity in the antitumor action of these complexes, as well, as tetrachloro(O,O-n-butyl-ethylenediamine-N,Nâ²-di-3-propanoate)platinum(IV) [I] and tetrachloro(O,O-n-pentyl-ethylenediamine-N,Nâ²-di-3-propanoate)platinum(IV) [IV], the antiproliferative action of these compounds was determined to human adenocarcinoma HeLa cells, to human myelogenous leukemia K562 cells and to normal immunocompetent cells, i.e., on human peripheral blood mononuclear PBMC cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 99, Issue 2, February 2005, Pages 488-496
Journal: Journal of Inorganic Biochemistry - Volume 99, Issue 2, February 2005, Pages 488-496
نویسندگان
Goran N. KaluÄeroviÄ, Vesna M. ÄinoviÄ, Zorica D. JuraniÄ, Tatjana P. StanojkoviÄ, Tibor J. Sabo,