کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10574944 | 976680 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interaction of polypyridyl ruthenium (II) complex containing asymmetric ligand with DNA
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Interaction of polypyridyl ruthenium (II) complex containing asymmetric ligand with DNA Interaction of polypyridyl ruthenium (II) complex containing asymmetric ligand with DNA](/preview/png/10574944.png)
چکیده انگلیسی
A novel asymmetric bidentate ruthenium (II) complex, [Ru(bpy)2(PYNI)]2+ (bpy = 2,2â²-bipyridine, PYNI = 2-(2â²-pyridyl)naphthoimidazole), has been synthesized and characterized by elemental analysis, ES-MS (electrospray mass spectra) and 1H NMR. The electrochemical behaviors of this complex were studied by cyclic voltammetry. DNA interaction studies suggest that [Ru(bpy)2(PYNI)]2+ binds to calf thymus DNA (CT-DNA) in an intercalative mode. Interestingly, this new Ru(II) complex has also been found to promote cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Inorganic Biochemistry - Volume 99, Issue 2, February 2005, Pages 530-537
Journal: Journal of Inorganic Biochemistry - Volume 99, Issue 2, February 2005, Pages 530-537
نویسندگان
Yun-Jun Liu, Hui Chao, Li-Feng Tan, Yi-Xian Yuan, Wei Wei, Liang-Nian Ji,