Synthesis and antimicrobial activity of copper(II) and silver(I) complexes of hydroxynitrocoumarins: X-ray crystal structures of [Cu(hnc)2(H2O)2] · 2H2O and [Ag(hnc)] (hncH = 4-hydroxy-3-nitro-2H-chromen-2-one)

A series of silver complexes of coumarin-based ligands showed significant anti-microbial activity, particularly against the clinically important methicillin-resistant Staphylococcus aureus (MRSA) bacterium and also demonstrated good activity, comparable to that of the commercial fungicides clortrimazole and ketoconazole, against a clinical isolate of the fungal pathogen Candida albicans.